Faculty Profile
Ramkumar Manthari
Assistant Professor, Biotechnology, GSS , VSP
Education
Ph. D.Email ID
rmanthar@gitam.edu
Education
Ph. D.Research Areas
- Neurotoxicology
- Autophagy
Education
| Degree Name | Institute & College name | Year of Graduation/Award |
|---|---|---|
| Doctor of Philosophy | Sri Venkateswara University Tirupati | 2015 |
| Master of Science | Acharya Nagarjuna University Guntur | 2009 |
| Bachelor of Science | Sir C R Reddy College Eluru | 2007 |
Experience
| Designation | Organization | From Date | To Date |
|---|---|---|---|
| ASSISTANT PROFESSOR | SHANXI AGRICULTURAL UNIVERSITY | 01-03-2019 | 31-07-2020 |
| POSTDOCTORAL FELLOW | SHANXI AGRICULTURAL UNIVERSITY | 01-07-2016 | 31-01-2019 |
| RESEARCH ASSOCIATE | SRI VENKATESWARA UNIVERSITY | 01-04-2015 | 30-06-2016 |
| JUNIOR RESEARCH FELLOW (DRDE SPONSORED PROJECT) | SRI VENKATESWARA UNIVERSITY | 03-12-2012 | 31-03-2015 |
| PROJECT ASSISTANT DST PURSE | SRI VENKATESWARA UNIVERSITY | 01-12-2011 | 30-04-2012 |
| JUNIOR RESEARCH FELLOW (DRDE SPONSORED PROJECT) | SRI VENKATESWARA UNIVERSITY | 01-12-2009 | 30-11-2011 |
Awards
| Award name | Award Organization | Awarded year |
|---|---|---|
| Young Scientist Award | Voice of Indian Concern for the Environment, Mumbai | 2021 |
| Best Oral Presentation | Sarvasumana Association, Bangalore | 2015 |
| Research Associateship | Indian Council of Medical Research, New Delhi | 2015 |
| Young Scientist Award | Vikrama Simhapuri University, Nellore | 2014 |
| Young Scientist Award | Vikrama Simhapuri University, Nellore | 2012 |
The Effects of Fluoride on the Gap Junctional Intercellular Communication of Rats OsteoblastBiological Trace Element Research, Scopus, JAN-2020, 193, 195-203
Selfrecovery study of the adverse effects of fluoride on small intestine Involvement of pyroptosis induced inflammationScience of the Total Environment, Scopus, NOV-2020, 742, 140533
Calcium relieves fluoride induced bone damage through the PI3K AKT pathwayFood & Function, Scopus, JAN-2020, 11, 1155-1164
Chronic arsenic exposure lowered sperm motility via impairing ultramicrostructure and key proteins expressions of sperm acrosome and flagellum formation during spermiogenesis in male miceScience of the Total Environment, Scopus, MAY-2020, 734, 139233
Arsenic induced Autophagic Alterations and Mitochondrial Impairments in HPGS Axis of Mature Male Mice Offspring (F1generation) A persistent toxicity studyToxicology Letters, Scopus, JUN-2020, 326, 83-98
Arsenic induces dysfunctional autophagy via dual regulation of mTOR pathway and Beclin1 Vps34 PI3K complex in MLTC1 cellsJournal of Hazardous Materials, Scopus, JUN-2020, 391, 122227
Immune disruption occurs through altered gut microbiome and NOD2 in arsenic induced mice Correlation with colon cancer markersChemosphere, Scopus, MAY-2020, 246, 125791
Effect of arsenic and or fluoride gestational exposure on renal autophagy in offspring miceChemosphere, Scopus, FEB-2020, 241, 124861
Arsenic influences spermatogenesis by disorganizing the elongation of spermatids in adult male miceChemosphere, Scopus, JAN-2020, 238, 124650
Fluoride induced mitochondrial impairment and PINK1 mediated mitophagy in Leydig cells of mice In vivo and in vitro studiesEnvironmental Pollution, Scopus, JAN-2020, 256, 113438
Influence of calcium supplementation against fluoride mediated osteoblasts impairment in vitro Involvement of canonical Wnt # catenin signaling pathwayJournal of Agricultural and Food Chemistry, Scopus, AUG-2019, 67, 10285-10295
Calcium alleviates fluoride induced bone damage by inhibiting endoplasmic reticulum stress and mitochondrial dysfunctionJournal of Agricultural and Food Chemistry, Scopus, AUG-2019, 67, 10832-10843
Paternal exposure to arsenic resulted in oxidative stress, autophagy, and mitochondrial impairments in the HPGS axis of pubertal male offspringChemosphere, Scopus, DEC-2019, 236, 124325
Fluoride Interferes with the Sperm Fertilizing Ability via Downregulated SPAM1, ACR, and PRSS21 Expression in Rat EpididymisJournal of Agricultural and Food Chemistry, Scopus, MAY-2019, 67, 5240-5249
Fluoride induces autoimmune orchitis involved with enhanced IL17A secretion in mice testisJournal of Agricultural and Food Chemistry, Scopus, JAN-2019, 67, 13333-13343
GSTO1 acts as a mediator in sodium fluoride induced alterations of learning and memory related factors expressions in the hippocampus cell lineChemosphere, Scopus, JUL-2019, 226, 201-209
Effects of Fluoride on Autophagy in Mouse Sertoli CellsBiological Trace Element Research, Scopus, JAN-2019, 187, 499-505
Effect of fluoride exposure on anxiety and depression like behavior in mouseChemosphere, Scopus, JAN-2019, 215, 454-460
Fluoride induces apoptosis and autophagy through the IL17 signaling pathway in mice hepatocytesArchives of Toxicology, Scopus, NOV-2018, 92, 3277-3289
Arsenic induces autophagy in developmental mouse cerebral cortex and hippocampus by inhibiting PI3K Akt mTOR signaling pathway involvement of blood brain barriers tight junction proteinsArchives of Toxicology, Scopus, NOV-2018, 92, 3255-3275
Fluoride altered rats blood testis barrier by affecting the F actin via IL1aChemosphere, Scopus, AUG-2018, 211, 826-833
Arsenic Induced Autophagy in the Developing Mouse Cerebellum Involvement of the Blood Brain Barriers Tight Junction Proteins and the PI3K Akt mTOR Signaling PathwayJournal of Agricultural and Food Chemistry, Scopus, AUG-2018, 66, 8602-8614
Alterations in epididymal proteomics and antioxidant activity of mice exposed to fluorideArchives of Toxicology, Scopus, JAN-2018, 92, 169-180
Effects of Fluoride and or Sulfur Dioxide on Morphology and DNA Integrity in Rats Hepatic TissueBiological Trace Element Research, Scopus, JUN-2018, 183, 335-341
Effects of different Ca2 level on fluoride induced apoptosis pathway of endoplasmic reticulum in the rabbit osteoblast in vitroFood and Chemical Toxicology, Scopus, JUN-2018, 116, 189-195
Effect of gestational exposure to arsenic on puberty in offspring female miceChemosphere, Scopus, JUL-2018, 202, 119-126
TGF1 acts as mediator in fluoride induced autophagy in the mouse osteoblast cellsFood and Chemical Toxicology, Scopus, MAY-2018, 115, 26-33
Abnormal spermatogenesis following sodium fluoride exposure is associated with the downregulation of CREM and ACT in the mouse testis Toxicology and Industrial Health, Scopus, MAR-2018, 34, 219-227
Coexposure to fluoride and sulfur dioxide on histological alteration and DNA damage in rat brainJournal of Biochemical and Molecular Toxicology, Scopus, FEB-2018, 32, 22023
Influence of age on arsenic induced behavioral and cholinergic perturbations Amelioration with zinc and a tocopherolHuman & Experimental Toxicology, Scopus, MAR-2018, 37, 295-308
Ameliorative Effect of VE, IGFI, and hCG on the Fluoride Induced Testosterone Release Suppression in Mice Leydig CellsBiological Trace Element Research, Scopus, JAN-2018, 181, 95-103
Effects of fluoride on synapse morphology and myelin damage in mouse hippocampusChemosphere, Scopus, MAR-2018, 194, 628-633
Protective Effects of Zinc and Vitamin E for Arsenic Induced Mitochondrial Oxidative Damage in Rat BrainCurrent Trends in Biotechnology and Pharmacy, Scopus, JUL-2017, 11, 67-83
Lead Induced alterations in Behavior and Brain Cholinergic System in Female Rats Ameliorative Effect of TocopherolIndo American Journal of Pharmaceutical Research, Others, OCT-2015, 5, 3281-3292
Monoisoamyl 2,3 dimercaptosuccinic acid attenuates arsenic induced toxicity Behavioral and neurochemical approachEnvironmental Toxicology and Pharmacology, Scopus, JUL-2013, 36, 231-242
Monoisoamyl 2,3 dimercaptosuccinic acid attenuates arsenic induced toxicity Behavioral and neurochemical approachEnvironmental Toxicology and Pharmacology, Scopus, JUL-2013, 36, 231-242
Exposure to Metal Mixture of Lead and Arsenic Impacts Superoxide Dismutase Activity and Expression in Rat BrainCurrent Trends in Biotechnology and Pharmacy, Scopus, JUL-2012, 6, 364-372
Perinatal lead exposure alters postnatal cholinergic and aminergic system in rat brain reversal effect of calcium coadministrationInternational Journal of Developmental Neuroscience, Scopus, JUN-2012, 30, 343-350
Calcium Addition Potentially Reverses Lead and Manganese Induced Enzymatic and Behavioral Alterations in RatsCurrent Trends in Biotechnology and Pharmacy, Scopus, APR-2011, 5, 1193-1205
| Board name | Journal name |
|---|---|
| Editorial Board | Journal of Veterinary Medicine and Animal Sciences |
| Editorial Board | Austin Journal of Invitro Fertilization |
| Board name | Journal name |
|---|
| Seminar name | Organized by | Venue | Start date | End date | Title of the paper presented | Role | Co presenter |
|---|---|---|---|---|---|---|---|
| National | DST PURSE Centre, Sri Venkateswara University, Tirupati | DST PURSE Centre, Sri Venkateswara University, Tirupati | 24-Feb-2012 | 25-Feb-2012 | Reversal Effects of Nutrient Metals against Arsenic Induced Behavioral and Biochemical Perturbations in Albino Rat | Participated | |
| National | Department of Biotechnology, Acharya Nagarjuna University, Nagarjuna Nagar | Department of Biotechnology, Acharya Nagarjuna University, Nagarjuna Nagar | 24-Sep-2011 | 26-Sep-2011 | Reversal effect of MiADMSA against Chronic Arsenic toxicity Behavioral and Neurochemical Approach | Participated | |
| National | Department of Zoology, Bangalore University, Bengaluru | Department of Zoology, Bangalore University, Bengaluru | 12-Oct-2009 | 13-Oct-2009 | Protective Role of Nutritional Supplements against Lead (or) Manganese Induced Neurotoxicity | Participated |
| Seminar name | Organized by | Venue | Start date | End date | Title of the paper presented | Role | Co presenter |
|---|---|---|---|---|---|---|---|
| International | Indian Institute of Sciences, Bangalore | Indian Institute of Sciences, Bangalore | 16-Jan-2020 | 18-Jan-2020 | Arsenic Induces Autophagy in Developmental Mouse Cerebral Cortex by Inhibiting Blood Brain Barriers Tight Junction Proteins | Participated | |
| International | College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu, Shanxi Province, PR China | Shanxi Agricultural University, Taigu, Shanxi Province, PR China | 14-Sep-2019 | 16-Sep-2019 | Arsenic Induced Autophagy in Developmental Brain Involvement of Blood Brain Barriers Tight Junction Proteins | Participated | |
| International | Telangana Academy of Sciences (TAS) and National Institute of Technology (NIT), Warangal | National Institute of Technology (NIT), Warangal | 22-Dec-2018 | 24-Dec-2018 | Arsenic Induced Autophagy in Developing Mouse Cerebellum Involvement of BloodBrain Barriers Tight Junction Proteins andor PI3KAktmTOR Signaling Pathway | Participated | |
| International | College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu, Shanxi Province, PR China | Shanxi Agricultural University, Taigu, Shanxi Province, PR China | 14-Jul-2017 | 16-Jul-2017 | Developmental Effect of Arsenic on Protein and mRNA Expression levels of Autophagic Pathway in Mice Brain Regions | Participated | |
| International | Department of Zoology, Sri Venkateswara University, Tirupati | Sri Venkateswara University, Tirupati | 21-Dec-2016 | 23-Dec-2016 | Protective Effects of Zinc and VitaminE for Arsenic Induced Mitochondrial Oxidative Damage in Rat Brain | Participated | |
| International | College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu, Shanxi Province, PR China | Shanxi Agricultural University, Taigu, Shanxi Province, PR China | 09-Oct-2016 | 12-Oct-2016 | Influence of Age on Arsenic Induced Mitochondrial Oxidative Stress and Apoptosis Reversal Effect of Zinc and Tocopherol | Participated | |
| International | Sarvasumana Association, Bangalore | Jyothi Nivas College, Bangalore | 09-Dec-2015 | 10-Dec-2015 | Influence of Age on Arsenic Induced Behavioral and Neurochemical Perturbations Amelioration with Zinc and tocopherol | Participated | |
| International | Department of Biotechnology, Vikrama Simhapuri University, Nellore | Vikrama Simhapuri University, Nellore | 01-Aug-2014 | 03-Aug-2014 | Response of Arsenic Induced Alterations in Postnatal cholinergic, Aminergic system and Apoptotic Caspases in Different Rat Brain Regions to Essential Metals and a Chelating Agent (Monoisoamyl 2,3dimercaptosuccinic acid) | Participated | |
| International | Department of Chemistry, Vikrama Simhapuri University, Nellore | Vikrama Simhapuri University, Nellore | 27-Dec-2013 | 29-Dec-2013 | Prenatal and Lactational Arsenic Exposure Enhanced Oxidative Stress and Altered Bioenergetics System in Offspring Rats Brain Specific Regions Combination Therapy with Tocopherol and MiADMSA | Participated | |
| International | Department of Zoology, Sri Venkateswara University, Tirupati | Sri Venkateswara University, Tirupati | 17-Dec-2013 | 19-Dec-2013 | Developmental Neurotoxicity of Arsenic Protective Effects of Calcium, Zinc and Monoisoamyl 2, 3dimercaptosuccinic acid (MiADMSA) | Participated | |
| International | Department of Chemistry, Vikrama Simhapuri University, Nellore | Vikrama Simhapuri University, Nellore | 18-Dec-2012 | 19-Dec-2012 | Influence of Age on Arsenic Induced Brain Region Specific Perturbations in Rat Chelation Therapy with MiADMSA | Participated | |
| International | Department of Marine Biology, Vikrama Simhapuri University, Nellore | Vikrama Simhapuri University, Nellore | 15-Jul-2012 | 17-Jul-2012 | MiADMSA Abrogates Arsenic Induced Alterations in Behavioral Activities and the Expression Levels of Antioxidant Systems in the Albino Rat | Participated | |
| International | Department of Zoology and Aquaculture, Acharya Nagarjuna University, Nagarjuna Nagar | Department of Zoology and Aquaculture, Acharya Nagarjuna University, Nagarjuna Nagar | 12-Feb-2011 | 14-Feb-2011 | Metal Induced Perturbations in Hepatic Mitochondrial Energetics and Oxidative Stress in Albino Rat | Participated | |
| International | Department of Biotechnology and Environmental Sciences, Thapar University, Patiala | Department of Biotechnology and Environmental Sciences, Thapar University, Patiala | 11-Nov-2010 | 13-Nov-2010 | Nanometals Reduce the Arsenic Induced Oxidative Stress in Rat Brain | Participated | |
| International | Department of Zoology, Bangalore University, Bengaluru | Department of Zoology, Bangalore University, Bengaluru | 29-Jul-2010 | 31-Jul-2010 | Metal Induced Perturbations in Selected Hepatic Mitochondrial and Cytosolic Enzymes | Participated | |
| International | Department of Biotechnology and Nanotechnology, Acharya Nagarjuna University, Guntur | Department of Biotechnology and Nanotechnology, Acharya Nagarjuna University, Guntur | 19-Dec-2009 | 21-Dec-2009 | Assessment of Lead Induced Neurotoxicity Behavioral and Neurochemical Approach | Participated | |
| International | Department of Zoology, Sri Venkateswara University, Tirupati | Department of Zoology, Sri Venkateswara University, Tirupati | 25-Jul-2009 | 27-Jul-2009 | Perturbations in Brain Enzymes and Behavioral Functions of Lead and Manganese Exposed Rats | Participated | |
| International | Department of Biotechnology, Koneru Lakshmaiah College of Engineering (KLCE), Vaddeswaram, Guntur | Department of Biotechnology, Koneru Lakshmaiah College of Engineering (KLCE), Vaddeswaram, Guntur | 20-Feb-2009 | 20-Feb-2009 | Molecular Characterization of Anaerobic Fungi | Participated |
| Name of the award | Awarded by | Awarded year |
|---|---|---|
| Research Associateship | Indian Council for Medical Research | 2015 |
| Title | Type | Organized by | Venue | Start date | End date | Role |
|---|---|---|---|---|---|---|
| Training Stem Cell Techniques | Training of tutors | National Brain Research Centre, Manesar, Haryana | National Brain Research Centre, Manesar, Haryana | 01-May-2016 | 06-May-2016 | Participated |
| National Workshop on Molecular Diagnostics for Identification of Microorganisms in Aquaculture MIMA2013 | Training of tutors | Department of Marine Biology, Vikrama Simmhapuri University, Nellore | Department of Marine Biology, Vikrama Simmhapuri University, Nellore | 27-Nov-2013 | 29-Nov-2013 | Participated |
| National Workshop on Advanced Methods of Studying Brain and Behavior | Training of tutors | Department of Zoology, Sri Venkateswara University, Tirupati | Department of Zoology, Sri Venkateswara University, Tirupati | 15-Feb-2011 | 18-Feb-2011 | Participated |
| Training on Animal Cell Culture | Training of tutors | Sri Raghavendra Biotechnologies Pvt. Ltd., Bangalore | Sri Raghavendra Biotechnologies Pvt. Ltd., Bangalore | 29-Dec-2008 | 03-Jan-2009 | Participated |
| Title | Type | Organized by | Venue | Start date | End date | Role |
|---|
| Organization name | Membership category | Membership type |
|---|---|---|
| Society for Biotechnologists India | Life | Member |