Ramkumar  Manthari

Ramkumar Manthari

Assistant Professor, Biotechnology, GSS , VSP

Education
Ph. D.
Email ID
rmanthar@gitam.edu
Education
Ph. D.
Research Areas
  • Neurotoxicology
  • Autophagy

Education

Degree Name Institute & College name Year of Graduation/Award
Doctor of Philosophy Sri Venkateswara University Tirupati 2015
Master of Science Acharya Nagarjuna University Guntur 2009
Bachelor of Science Sir C R Reddy College Eluru 2007

Experience

Designation Organization From Date To Date
ASSISTANT PROFESSOR SHANXI AGRICULTURAL UNIVERSITY 01-03-2019 31-07-2020
POSTDOCTORAL FELLOW SHANXI AGRICULTURAL UNIVERSITY 01-07-2016 31-01-2019
RESEARCH ASSOCIATE SRI VENKATESWARA UNIVERSITY 01-04-2015 30-06-2016
JUNIOR RESEARCH FELLOW (DRDE SPONSORED PROJECT) SRI VENKATESWARA UNIVERSITY 03-12-2012 31-03-2015
PROJECT ASSISTANT DST PURSE SRI VENKATESWARA UNIVERSITY 01-12-2011 30-04-2012
JUNIOR RESEARCH FELLOW (DRDE SPONSORED PROJECT) SRI VENKATESWARA UNIVERSITY 01-12-2009 30-11-2011

Awards

Award name Award Organization Awarded year
Young Scientist Award Voice of Indian Concern for the Environment, Mumbai 2021
Best Oral Presentation Sarvasumana Association, Bangalore 2015
Research Associateship Indian Council of Medical Research, New Delhi 2015
Young Scientist Award Vikrama Simhapuri University, Nellore 2014
Young Scientist Award Vikrama Simhapuri University, Nellore 2012

The Effects of Fluoride on the Gap Junctional Intercellular Communication of Rats OsteoblastBiological Trace Element Research, Scopus, JAN-2020, 193, 195-203

Selfrecovery study of the adverse effects of fluoride on small intestine Involvement of pyroptosis induced inflammationScience of the Total Environment, Scopus, NOV-2020, 742, 140533

Calcium relieves fluoride induced bone damage through the PI3K AKT pathwayFood & Function, Scopus, JAN-2020, 11, 1155-1164

Chronic arsenic exposure lowered sperm motility via impairing ultramicrostructure and key proteins expressions of sperm acrosome and flagellum formation during spermiogenesis in male miceScience of the Total Environment, Scopus, MAY-2020, 734, 139233

Arsenic induced Autophagic Alterations and Mitochondrial Impairments in HPGS Axis of Mature Male Mice Offspring (F1generation) A persistent toxicity studyToxicology Letters, Scopus, JUN-2020, 326, 83-98

Arsenic induces dysfunctional autophagy via dual regulation of mTOR pathway and Beclin1 Vps34 PI3K complex in MLTC1 cellsJournal of Hazardous Materials, Scopus, JUN-2020, 391, 122227

Immune disruption occurs through altered gut microbiome and NOD2 in arsenic induced mice Correlation with colon cancer markersChemosphere, Scopus, MAY-2020, 246, 125791

Effect of arsenic and or fluoride gestational exposure on renal autophagy in offspring miceChemosphere, Scopus, FEB-2020, 241, 124861

Arsenic influences spermatogenesis by disorganizing the elongation of spermatids in adult male miceChemosphere, Scopus, JAN-2020, 238, 124650

Fluoride induced mitochondrial impairment and PINK1 mediated mitophagy in Leydig cells of mice In vivo and in vitro studiesEnvironmental Pollution, Scopus, JAN-2020, 256, 113438

Influence of calcium supplementation against fluoride mediated osteoblasts impairment in vitro Involvement of canonical Wnt # catenin signaling pathwayJournal of Agricultural and Food Chemistry, Scopus, AUG-2019, 67, 10285-10295

Calcium alleviates fluoride induced bone damage by inhibiting endoplasmic reticulum stress and mitochondrial dysfunctionJournal of Agricultural and Food Chemistry, Scopus, AUG-2019, 67, 10832-10843

Paternal exposure to arsenic resulted in oxidative stress, autophagy, and mitochondrial impairments in the HPGS axis of pubertal male offspringChemosphere, Scopus, DEC-2019, 236, 124325

Fluoride Interferes with the Sperm Fertilizing Ability via Downregulated SPAM1, ACR, and PRSS21 Expression in Rat EpididymisJournal of Agricultural and Food Chemistry, Scopus, MAY-2019, 67, 5240-5249

Fluoride induces autoimmune orchitis involved with enhanced IL17A secretion in mice testisJournal of Agricultural and Food Chemistry, Scopus, JAN-2019, 67, 13333-13343

GSTO1 acts as a mediator in sodium fluoride induced alterations of learning and memory related factors expressions in the hippocampus cell lineChemosphere, Scopus, JUL-2019, 226, 201-209

Effects of Fluoride on Autophagy in Mouse Sertoli CellsBiological Trace Element Research, Scopus, JAN-2019, 187, 499-505

Effect of fluoride exposure on anxiety and depression like behavior in mouseChemosphere, Scopus, JAN-2019, 215, 454-460

Fluoride induces apoptosis and autophagy through the IL17 signaling pathway in mice hepatocytesArchives of Toxicology, Scopus, NOV-2018, 92, 3277-3289

Arsenic induces autophagy in developmental mouse cerebral cortex and hippocampus by inhibiting PI3K Akt mTOR signaling pathway involvement of blood brain barriers tight junction proteinsArchives of Toxicology, Scopus, NOV-2018, 92, 3255-3275

Fluoride altered rats blood testis barrier by affecting the F actin via IL1aChemosphere, Scopus, AUG-2018, 211, 826-833

Arsenic Induced Autophagy in the Developing Mouse Cerebellum Involvement of the Blood Brain Barriers Tight Junction Proteins and the PI3K Akt mTOR Signaling PathwayJournal of Agricultural and Food Chemistry, Scopus, AUG-2018, 66, 8602-8614

Alterations in epididymal proteomics and antioxidant activity of mice exposed to fluorideArchives of Toxicology, Scopus, JAN-2018, 92, 169-180

Effects of Fluoride and or Sulfur Dioxide on Morphology and DNA Integrity in Rats Hepatic TissueBiological Trace Element Research, Scopus, JUN-2018, 183, 335-341

Effects of different Ca2 level on fluoride induced apoptosis pathway of endoplasmic reticulum in the rabbit osteoblast in vitroFood and Chemical Toxicology, Scopus, JUN-2018, 116, 189-195

Effect of gestational exposure to arsenic on puberty in offspring female miceChemosphere, Scopus, JUL-2018, 202, 119-126

TGF1 acts as mediator in fluoride induced autophagy in the mouse osteoblast cellsFood and Chemical Toxicology, Scopus, MAY-2018, 115, 26-33

Abnormal spermatogenesis following sodium fluoride exposure is associated with the downregulation of CREM and ACT in the mouse testis Toxicology and Industrial Health, Scopus, MAR-2018, 34, 219-227

Coexposure to fluoride and sulfur dioxide on histological alteration and DNA damage in rat brainJournal of Biochemical and Molecular Toxicology, Scopus, FEB-2018, 32, 22023

Influence of age on arsenic induced behavioral and cholinergic perturbations Amelioration with zinc and a tocopherolHuman & Experimental Toxicology, Scopus, MAR-2018, 37, 295-308

Ameliorative Effect of VE, IGFI, and hCG on the Fluoride Induced Testosterone Release Suppression in Mice Leydig CellsBiological Trace Element Research, Scopus, JAN-2018, 181, 95-103

Effects of fluoride on synapse morphology and myelin damage in mouse hippocampusChemosphere, Scopus, MAR-2018, 194, 628-633

Protective Effects of Zinc and Vitamin E for Arsenic Induced Mitochondrial Oxidative Damage in Rat BrainCurrent Trends in Biotechnology and Pharmacy, Scopus, JUL-2017, 11, 67-83

Lead Induced alterations in Behavior and Brain Cholinergic System in Female Rats Ameliorative Effect of TocopherolIndo American Journal of Pharmaceutical Research, Others, OCT-2015, 5, 3281-3292

Monoisoamyl 2,3 dimercaptosuccinic acid attenuates arsenic induced toxicity Behavioral and neurochemical approachEnvironmental Toxicology and Pharmacology, Scopus, JUL-2013, 36, 231-242

Monoisoamyl 2,3 dimercaptosuccinic acid attenuates arsenic induced toxicity Behavioral and neurochemical approachEnvironmental Toxicology and Pharmacology, Scopus, JUL-2013, 36, 231-242

Exposure to Metal Mixture of Lead and Arsenic Impacts Superoxide Dismutase Activity and Expression in Rat BrainCurrent Trends in Biotechnology and Pharmacy, Scopus, JUL-2012, 6, 364-372

Perinatal lead exposure alters postnatal cholinergic and aminergic system in rat brain reversal effect of calcium coadministrationInternational Journal of Developmental Neuroscience, Scopus, JUN-2012, 30, 343-350

Calcium Addition Potentially Reverses Lead and Manganese Induced Enzymatic and Behavioral Alterations in RatsCurrent Trends in Biotechnology and Pharmacy, Scopus, APR-2011, 5, 1193-1205

Board name Journal name
Editorial Board Journal of Veterinary Medicine and Animal Sciences
Editorial Board Austin Journal of Invitro Fertilization
Board name Journal name
Seminar name Organized by Venue Start date End date Title of the paper presented Role Co presenter
National DST PURSE Centre, Sri Venkateswara University, Tirupati DST PURSE Centre, Sri Venkateswara University, Tirupati 24-Feb-2012 25-Feb-2012 Reversal Effects of Nutrient Metals against Arsenic Induced Behavioral and Biochemical Perturbations in Albino Rat Participated
National Department of Biotechnology, Acharya Nagarjuna University, Nagarjuna Nagar Department of Biotechnology, Acharya Nagarjuna University, Nagarjuna Nagar 24-Sep-2011 26-Sep-2011 Reversal effect of MiADMSA against Chronic Arsenic toxicity Behavioral and Neurochemical Approach Participated
National Department of Zoology, Bangalore University, Bengaluru Department of Zoology, Bangalore University, Bengaluru 12-Oct-2009 13-Oct-2009 Protective Role of Nutritional Supplements against Lead (or) Manganese Induced Neurotoxicity Participated
Seminar name Organized by Venue Start date End date Title of the paper presented Role Co presenter
International Indian Institute of Sciences, Bangalore Indian Institute of Sciences, Bangalore 16-Jan-2020 18-Jan-2020 Arsenic Induces Autophagy in Developmental Mouse Cerebral Cortex by Inhibiting Blood Brain Barriers Tight Junction Proteins Participated
International College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu, Shanxi Province, PR China Shanxi Agricultural University, Taigu, Shanxi Province, PR China 14-Sep-2019 16-Sep-2019 Arsenic Induced Autophagy in Developmental Brain Involvement of Blood Brain Barriers Tight Junction Proteins Participated
International Telangana Academy of Sciences (TAS) and National Institute of Technology (NIT), Warangal National Institute of Technology (NIT), Warangal 22-Dec-2018 24-Dec-2018 Arsenic Induced Autophagy in Developing Mouse Cerebellum Involvement of BloodBrain Barriers Tight Junction Proteins andor PI3KAktmTOR Signaling Pathway Participated
International College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu, Shanxi Province, PR China Shanxi Agricultural University, Taigu, Shanxi Province, PR China 14-Jul-2017 16-Jul-2017 Developmental Effect of Arsenic on Protein and mRNA Expression levels of Autophagic Pathway in Mice Brain Regions Participated
International Department of Zoology, Sri Venkateswara University, Tirupati Sri Venkateswara University, Tirupati 21-Dec-2016 23-Dec-2016 Protective Effects of Zinc and VitaminE for Arsenic Induced Mitochondrial Oxidative Damage in Rat Brain Participated
International College of Animal Science and Veterinary Medicine, Shanxi Agricultural University, Taigu, Shanxi Province, PR China Shanxi Agricultural University, Taigu, Shanxi Province, PR China 09-Oct-2016 12-Oct-2016 Influence of Age on Arsenic Induced Mitochondrial Oxidative Stress and Apoptosis Reversal Effect of Zinc and Tocopherol Participated
International Sarvasumana Association, Bangalore Jyothi Nivas College, Bangalore 09-Dec-2015 10-Dec-2015 Influence of Age on Arsenic Induced Behavioral and Neurochemical Perturbations Amelioration with Zinc and tocopherol Participated
International Department of Biotechnology, Vikrama Simhapuri University, Nellore Vikrama Simhapuri University, Nellore 01-Aug-2014 03-Aug-2014 Response of Arsenic Induced Alterations in Postnatal cholinergic, Aminergic system and Apoptotic Caspases in Different Rat Brain Regions to Essential Metals and a Chelating Agent (Monoisoamyl 2,3dimercaptosuccinic acid) Participated
International Department of Chemistry, Vikrama Simhapuri University, Nellore Vikrama Simhapuri University, Nellore 27-Dec-2013 29-Dec-2013 Prenatal and Lactational Arsenic Exposure Enhanced Oxidative Stress and Altered Bioenergetics System in Offspring Rats Brain Specific Regions Combination Therapy with Tocopherol and MiADMSA Participated
International Department of Zoology, Sri Venkateswara University, Tirupati Sri Venkateswara University, Tirupati 17-Dec-2013 19-Dec-2013 Developmental Neurotoxicity of Arsenic Protective Effects of Calcium, Zinc and Monoisoamyl 2, 3dimercaptosuccinic acid (MiADMSA) Participated
International Department of Chemistry, Vikrama Simhapuri University, Nellore Vikrama Simhapuri University, Nellore 18-Dec-2012 19-Dec-2012 Influence of Age on Arsenic Induced Brain Region Specific Perturbations in Rat Chelation Therapy with MiADMSA Participated
International Department of Marine Biology, Vikrama Simhapuri University, Nellore Vikrama Simhapuri University, Nellore 15-Jul-2012 17-Jul-2012 MiADMSA Abrogates Arsenic Induced Alterations in Behavioral Activities and the Expression Levels of Antioxidant Systems in the Albino Rat Participated
International Department of Zoology and Aquaculture, Acharya Nagarjuna University, Nagarjuna Nagar Department of Zoology and Aquaculture, Acharya Nagarjuna University, Nagarjuna Nagar 12-Feb-2011 14-Feb-2011 Metal Induced Perturbations in Hepatic Mitochondrial Energetics and Oxidative Stress in Albino Rat Participated
International Department of Biotechnology and Environmental Sciences, Thapar University, Patiala Department of Biotechnology and Environmental Sciences, Thapar University, Patiala 11-Nov-2010 13-Nov-2010 Nanometals Reduce the Arsenic Induced Oxidative Stress in Rat Brain Participated
International Department of Zoology, Bangalore University, Bengaluru Department of Zoology, Bangalore University, Bengaluru 29-Jul-2010 31-Jul-2010 Metal Induced Perturbations in Selected Hepatic Mitochondrial and Cytosolic Enzymes Participated
International Department of Biotechnology and Nanotechnology, Acharya Nagarjuna University, Guntur Department of Biotechnology and Nanotechnology, Acharya Nagarjuna University, Guntur 19-Dec-2009 21-Dec-2009 Assessment of Lead Induced Neurotoxicity Behavioral and Neurochemical Approach Participated
International Department of Zoology, Sri Venkateswara University, Tirupati Department of Zoology, Sri Venkateswara University, Tirupati 25-Jul-2009 27-Jul-2009 Perturbations in Brain Enzymes and Behavioral Functions of Lead and Manganese Exposed Rats Participated
International Department of Biotechnology, Koneru Lakshmaiah College of Engineering (KLCE), Vaddeswaram, Guntur Department of Biotechnology, Koneru Lakshmaiah College of Engineering (KLCE), Vaddeswaram, Guntur 20-Feb-2009 20-Feb-2009 Molecular Characterization of Anaerobic Fungi Participated
Name of the award Awarded by Awarded year
Research Associateship Indian Council for Medical Research 2015
Title Type Organized by Venue Start date End date Role
Training Stem Cell Techniques Training of tutors National Brain Research Centre, Manesar, Haryana National Brain Research Centre, Manesar, Haryana 01-May-2016 06-May-2016 Participated
National Workshop on Molecular Diagnostics for Identification of Microorganisms in Aquaculture MIMA2013 Training of tutors Department of Marine Biology, Vikrama Simmhapuri University, Nellore Department of Marine Biology, Vikrama Simmhapuri University, Nellore 27-Nov-2013 29-Nov-2013 Participated
National Workshop on Advanced Methods of Studying Brain and Behavior Training of tutors Department of Zoology, Sri Venkateswara University, Tirupati Department of Zoology, Sri Venkateswara University, Tirupati 15-Feb-2011 18-Feb-2011 Participated
Training on Animal Cell Culture Training of tutors Sri Raghavendra Biotechnologies Pvt. Ltd., Bangalore Sri Raghavendra Biotechnologies Pvt. Ltd., Bangalore 29-Dec-2008 03-Jan-2009 Participated
Title Type Organized by Venue Start date End date Role
Organization name Membership category Membership type
Society for Biotechnologists India Life Member