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Umakant Sharma

Umakant Sharma

Associate Professor

Department of Life Sciences

GITAM School of Science

Visakhapatnam

Education

Ph. D.

Dr. Umakant Sharma completed his Ph.D. from AIIMS, New Delhi. He was an ICMR-Fellow. He had postdoctoral from University of Minnesota, USA. He was a Research Assistant Professor at University of Miami, USA. His primary research focuses on metagenomics, metabolomics, cancer, inflammatory, and infectious diseases and precisely on the development of novel personalized therapy using signature gut microbiome and metabolites for the treatment of Inflammatory bowel diseases and colon cancer.

Research Publications

  • 1. Sharma U, Olson RK, Erhart FN, Zhang L, Meng J, Segura B, Sharma M, Banerjee S, Saluja AK, Ramakrishnan S, Abreu MT and Roy S. Prescription opioids induce gut dysbiosis and exacerbate Inflammatory Bowel Disease. J Crohns Colitis 2020: 14(6); 801-817. DOI: 10.1093/ecco-jcc/jjz188
  • 2. Vitari N, Jalodia R, Tao J, Kolli U, Singh S, Rodriguez LV, Sharma U, and Roy S. Morphine-induced intestinal microbial dysbiosis activates the classical complement pathway. Gut Microbes Reports 2025: 2 2527628. DOI: 10.1080/29933935.2025.2527628.
  • 3. Vitari N, Singh S, Tao J, Truitt B, Kolli U, Jalodia R, LaPorte KM, Abu Y, Antoine D, Sharma U, and Roy S. Morphine-induced intestinal microbial dysbiosis drives TLR-dependent IgA targeting of gram-positive bacteria and upregulation of CD11b and TLR2 on a sub-population of IgA+ B cells. Gut Microbes 2024: 16(1) 2417729. DOI: 10.1080/19490976.2024.2417729.
  • 4. Ghosh N, Kesh K, Singh PK, Sharma U, Chupikova I, Ramakrishnan S, and Roy S. Morphine use induces gastric microbial dysbiosis driving gastric inflammation through TLR2 signaling which is attenuated by proton pump inhibitor. Br J Pharmacol 2023: 180(12) 1582-1596. DOI: 10.1111/bph.16025.
  • 5. Zhang L, Meng J, Ban Y, Jalodia R, Chupikova I, Fernandez I, Brito N, Abreu MT, Ramakrishnan S, Sharma U and Roy S. Morphine tolerance is attenuated in germ-free mice and reversed by probiotics, implicating the role of gut microbiome. Proc Natl Acad Sci U S A 2019: 116(27) 13523-13532. DOI: 10.1073/pnas.1901182116

Ongoing Research Projects

  • Check Icon 1. Evaluation of therapeutic potential of synbiotics (probiotics+ prebiotics) and metabolite Consortia on Amelioration of Inflammation and Clinical Manifestations of Inflammatory bowel diseases (IBD) and Colon cancer.
  • Check Icon 2. Development of effective personalized therapies using gut microbiome and metabolites for the treatment of Inflammatory bowel diseases (IBD) and colon associated cancer (CAC).
  • Check Icon 3. Development of novel diagnostic tools using signature gut microbiome and metabolites for the diagnosis of Inflammatory bowel diseases (IBD) and colorectal cancer (CRC).
  • Check Icon 4. Drug Induced Dysregulation of Gut Microbiota and Systemic Inflammation Accelerate HIV-Associated Premature Aging in a murine Model of HIV.
  • Check Icon 5. Investigation of anti-inflammatory activity of natural compounds in In-vitro and In-vivo models.

Expertise

  • Check Icon 1. Research work on Gut microbiome, Microbial metabolites, Synbiotic therapy for treatment of IBD and Colon cancer
  • Check Icon 2. Research grant writing to receive the funding and Establishing research collaboration
  • Check Icon 3. Editorial board member and Reviewer of the Peer-reviewed International Journals
  • Check Icon 4. Mentoring Ph.D students and Research Scholars
  • Check Icon 5. Research experimentation in mouse model of IBD, Colon cancer and HIV.

Authored Books

  • Check Icon N/A
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