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Siva Nageswararao Gajula

Siva Nageswararao Gajula

Assistant Professor

Department of Pharmaceutical Analysis

GITAM School of Pharmacy

Visakhapatnam

Education

Ph. D.

Experienced pharmaceutical researcher specialized in drug metabolism and pharmacokinetics (DMPK) studies with proficiency in LC-MS/MS analysis. Skilled in small molecule structural characterization, biomarker quantification, and phytoconstituent identification. Holds a Ph.D. from NIPER Hyderabad and M.S. (Pharm.) from NIPER Ahmedabad. Recipient of merit-based scholarships and awards, demonstrating a strong commitment to academic excellence and scientific research.

Research Publications

  • Rao Gajula, S. N., Talari, S., Chilvery, S., Godugu, C., & Sonti, R. (2023). A unique in vivo pharmacokinetic profile, in vitro metabolic stability and hepatic first-pass metabolism of garcinol, a promising novel anticancer phytoconstituent, by liquid chromatography–mass spectrometry. RPS Pharmacy and Pharmacology Reports, 2(2), rqad017.
  • Rao Gajula, S. N., Talari, S., Nathani, T. N., Munjal, V., Rahman, Z., Dandekar, M. P., & Sonti, R. (2023). Effect of chronopharmacology and food on in vivo pharmacokinetic profile of mavacamten. Bioanalysis, 15(12), 695-706.
  • Gajula, S. N. R., Munjal, V., Talari, S., Rahman, Z., Dandekar, M. P., & Sonti, R. (2025). The Influence of a Rat Model of Depression and Gastric Ulcer on the Pharmacokinetics of Encorafenib. Biopharmaceutics & Drug Disposition, 46(2), 67-81.
  • Gajula, S. N. R., Patil, R. M., Rahman, Z., Dandekar, M. P., & Sonti, R. (2024). A Liquid Chromatography Coupled to Tandem Mass Spectrometry Method for Simultaneous Estimation of Saxagliptin and Avanafil: Application to Pharmacokinetic Drug‐Drug Interaction in Type 2 Diabetic Rat Model. Separation Science Plus, 7(11), e202400163.
  • Dandekar, M. P., Palepu, M. S. K., Satti, S., Jaiswal, Y., Singh, A. A., Dash, S. P., ... & Sonti, R. (2022). Multi-strain probiotic formulation reverses maternal separation and chronic unpredictable mild stress-generated anxiety-and depression-like phenotypes by modulating gut microbiome–brain activity in rats. ACS Chemical Neuroscience, 13(13), 1948-1965.

Ongoing Research Projects

  • Check Icon Pioneering Glycated Free Amino Acids as Prognostic Biomarkers in Triple-Negative Breast Cancer using LC-MS/MS Profiling

Expertise

  • Check Icon Conducting Drug metabolism and Pharmacokinetics (DMPK) studies
  • Check Icon Metabolomics and glycomics based disease biomarkers identification and quantification
  • Check Icon Handling of LC-MS/MS and other analytical instruments
  • Check Icon Structural characterization of small molecules
  • Check Icon Conducting various studies involved in drug development

Authored Books

  • Check Icon Handbook of Oxidative Stress in Cancer: Mechanistic Aspects
  • Check Icon Medicinal and Aromatic Plants
  • Check Icon Dosage Forms-Innovation and Future Perspectives
  • Check Icon Nanocarrier Vaccines: Biopharmaceutics‐Based Fast Track Development
  • Check Icon SARS-CoV-2 Variants and Global Population Vulnerability
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