Dhrubajyoti Chowdhury

DBT Ramalingaswami Fellowships

Department of Life Sciences

GITAM School of Science

Visakhapatnam

Education

Ph. D.

dchowdhu@gitam.edu

Social Media

Google Scholar Scopus

Scopus

ORCiD

Dhrubajyoti Chowdhury earned his Ph.D in Neuroscience at University of Navarra, Spain . His work identified the molecular mechanisms for the endocytosis of NMDA-type glutamate receptors (GluRs). During his postdoctoral research at University of California Davis, he identified PSD-95 palmitoylation as a critical mechanism regulating AMPA-type GluRs. Before joining GITAM, Dr. Chowdhury worked at Yale University as associate faculty studying the dynamic regulation of synaptic adhesion molecules.

Research Publications

K.P. de Arce*, A. Ribic*, D. Chowdhury*, K. Watters*, G.J. Thompson, B.G. Sanganahalli, E.T.C. Lippard, A. Rohlmann, S.M. Strittmatter, M. Missler, F. Hyder and T. Biederer (2023) ‘Concerted roles of LRRTM1 and SynCAM1 in organizing prefrontal cortex synapses and cognitive functions’, Nature Communications 14(1):459. *equal contribution
D. Chowdhury* and J.W. Hell (2019) ‘Ca2+/calmodulin binding to PSD-95 downregulates its palmitoylation and AMPARs in long-term depression’, Frontiers in Synaptic Neuroscience 11(6). * corresponding author
D. Chowdhury*, M. Turner*, T. Patriarchi, A. Hergarden, D. Anderson, Y. Zhang, J. Sung, C-Y. Chen, J.B. Ames and J.W. Hell (2018) ‘Ca2+/calmodulin binding to PSD-95 mediates homeostatic synaptic scaling down’, The EMBO Journal 37(1): 122-138.
D. Chowdhury, K. Watters and T. Biederer (2021) ‘Synaptic recognition molecules in development and disease’, Current Topics in Developmental Biology 142: 319-370.
L. Matt, K. Kim, A. Hergarden, T.Patriarchi, Z.A. Malik, D.K. Park, D. Chowdhury, O.R.Buonarati, P.B. Henderson, C. Gokcek-Sarac, Y. Zhang, D. Mohapatra, M. C. Horne, J. B. Ames and J.W. Hell (2018) ‘-Actinin anchors PSD-95 at postsynaptic sites’, Neuron 97 (5): 1094-1109.

Ongoing Research Projects

Molecular mechanisms of glutamate excitotoxicity
Role of palmitoylation in synaptic plasticity and pathology

Expertise

Cellular and molecular neuroscience
Glutamate receptors
Synapses
Signaling mechanisms
Plasticity